Anti-Human TNF-α, mFluor 610 (Clone: MAb11) 檢測試劑

TNF 分子靶點信息概述

• 分子名：TNF, tumor necrosis factor
• 基因家族：Tumor necrosis factor superfamily
• 別名：TNFSF2; DIF; TNF-alpha
• 曾用名：TNFA
• 全稱：TNF superfamily, member 2; tumor necrosis factor (TNF superfamily, member 2)

TNF 分子靶點綜述

TNF-α 為單核細胞、巨噬細胞、中性粒細胞、NK 細胞和 CD4+T 細胞產生的 17 kDa 細胞因子。它在免疫應答中具有多種調節功能，還可作為潛在的熱原。TNF-α對刺激物(感染因子或組織受損)產生應答后，在全身循環，激活中性粒細胞，改變血管內皮細胞的特性，調控其它組織的代謝活性，以及通過誘導局部凝血作用展現腫瘤殺傷活性。TNF-α 在關節組織和其它組織發生炎癥的發病機制具有重要作用。

人 Human TNF 分子靶點信息

• 分子名：TNF, tumor necrosis factor
• 別稱：
  • APC1 protein
  • cachectin
  • DIF
  • TNF superfamily, member 2
  • TNF-a
  • TNF-alpha
  • TNF, macrophage-derived
  • TNF, monocyte-derived
  • TNFA
  • TNFSF2
  • TNLG1F
  • tumor necrosis factor alpha
  • tumor necrosis factor ligand 1F
  • tumor necrosis factor ligand superfamily member 2
  • tumor necrosis factor-alpha
• 基因序列：NCBI_Gene: 7124
• 蛋白序列：UniProtKB: P01375

人 Human TNF靶點分子功能（預測）

Enables several functions, including identical protein binding activity; protease binding activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of macromolecule metabolic process; and regulation of apoptotic process. Acts upstream of or within several processes, including regulation of cellular protein metabolic process; regulation of gene expression; and regulation of signal transduction. Located in cell surface; extracellular space; and membrane raft. Is integral component of plasma membrane. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Biomarker of several diseases, including anemia (multiple); autoimmune disease (multiple); eye disease (multiple); kidney disease (multiple); and lung disease (multiple).